ANO1: MORE THAN JUST CALCIUM-ACTIVATED CHLORIDE CHANNEL IN CANCER

ANO1: More Than Just Calcium-Activated Chloride Channel in Cancer

ANO1, a calcium-activated chloride channel (CACC), is also known as transmembrane protein 16A (TMEM16A).It plays a vital role in the occurrence, development, metastasis, proliferation, and apoptosis of various malignant tumors.This article reviews the mechanism of ANO1 involved in the replication, proliferation, invasion and apoptosis of various ma

read more

Multi-Objective Grey Wolf Optimizer for Optimal Design of Switching Matrix for Shaded PV array Dynamic Reconfiguration

One of the worst negative phenomena faced by photovoltaic (PV) array is the operation under the shadow phenomenon, which significantly affects the generated power.Multiple local maximum power point (MPP) and unique global MPP are generated from the shaded array.Therefore, regular dispersion of the shadow falling on the PV array surface is a vital i

read more

Information Extraction From FDA Drug Labeling to Enhance Product-Specific Guidance Assessment Using Natural Language Processing

Towards the objectives of the UnitedStates Food and Drug Administration (FDA) generic drug science and research program, it is of vital importance in developing product-specific guidances (PSGs) with recommendations that can facilitate and guide generic product development.To generate a PSG, the assessor needs to retrieve supportive information abo

read more

Transcranial Magnetic Stimulation for Reducing the Relative Reinforcing Value of Food in Adult Patients With Obesity Pursuing Metabolic and Bariatric Surgery: Protocol for a Pilot, Within-Participants, Sham-Controlled Trial

BackgroundMetabolic and bariatric surgery (MBS) is the most effective and durable obesity treatment.However, there is heterogeneity in weight outcomes, which is partially attributed to variability in appetite and eating regulation.Patients with a strong desire to eat in response to the reward of palatable foods are more likely to overeat and experi

read more